| Characteristic | Details |
|---|---|
| Active Ingredient | Sildenafil Citrate |
| Available Dosages | 25 mg, 50 mg, 100 mg |
| Form | Tablet |
| Use | Erectile Dysfunction |
| Duration of Effect | Up to 4 hours |
| Visit Official Zenegra Page | |
Pharmacokinetics
The pharmacokinetics of Zenegra 100 mg involve absorption, distribution, metabolism, and excretion. Sildenafil citrate rapidly absorbs into the bloodstream, reaching peak plasma levels within 30 to 120 minutes. The bioavailability of sildenafil, approximately 40%, ensures effective systemic delivery.
Sildenafil distributes in the body, binding 96% to plasma proteins. Its metabolism occurs primarily in the liver through the CYP3A4 and CYP2C9 pathways. It transforms into an active metabolite, N-desmethylsildenafil, with half the potency of the parent compound. Excretion mainly occurs via the fecal route, with about 80% of the administered dose eliminated in this manner. The terminal half-life of sildenafil is around four hours.
How Should Zenegra Be Used?
Zenegra 50 mg should be taken approximately one hour before planned sexual activity. The tablet should be swallowed whole with water, not chewed or crushed. It’s important to avoid heavy or fatty meals close to the time of consumption, as these can slow the absorption rate and delay its effects.
The recommended starting dose is 50 mg, but it can be adjusted to 25 mg or increased to 100 mg based on efficacy and tolerance. The maximum recommended dosing frequency is once per day. Patients should not exceed this frequency to prevent adverse reactions. Detailed guidance can be found at NCBI.
Who Can and Cannot Take Zenegra?
Zenegra 25 mg suits adults over the age of 18 who experience erectile dysfunction. It is unsuitable for women and children. Men with heart problems, such as severe cardiac failure or unstable angina, should not take Zenegra.
Patients with severe hepatic impairment or end-stage kidney disease requiring dialysis should avoid it. Those with retinitis pigmentosa, non-arteritic anterior ischemic optic neuropathy, or who have had a stroke should consult a healthcare provider before using Zenegra.
Pregnancy and Breastfeeding
Zenegra is not indicated for use in women. There is no safety data available regarding its use during pregnancy or breastfeeding. Women who are pregnant or nursing should avoid any contact or accidental ingestion of Zenegra.
For individuals with reproductive partners who are pregnant or breastfeeding, discussion with a healthcare professional is recommended. This ensures safety and minimizes risk to the partner and the developing child.
Zenegra Side Effects
Common side effects include headache, flushing, dyspepsia, nasal congestion, dizziness, and visual disturbances. These symptoms are usually mild and temporary. Patients experiencing prolonged or severe side effects should seek medical attention.
Serious adverse effects include sudden vision loss, sudden hearing decrease or loss, and an erection lasting more than four hours (priapism). These require immediate medical intervention. Users should remain vigilant for symptoms and contact healthcare professionals as needed.
Is Non-Prescription Zenegra Available?
Zenegra requires a prescription. It should only be obtained through a licensed healthcare provider. Non-prescription or counterfeit products pose serious health risks.
Purchasing Zenegra through unauthorized sources increases the risk of consuming unsafe or ineffective substances. Patients should only acquire Zenegra from trusted pharmacies to ensure authenticity and safety.
| Aspect | Details |
|---|---|
| Consultation Requirement | Mandatory |
| Safety Concerns | Counterfeit Risk |